What is dbNSFP? 

dbNSFP is a database developed for functional prediction and annotation of all potential non-synonymous single-nucleotide variants (nsSNVs) in the human genome. Its current version is based on the GENCODE release 47 (Ensembl version 113) and includes a total of 83,681,419 potential nsSNVs and ssSNVs (splicing-site SNVs) of all known protein-coding genes in the human genome.  

The database compiles prediction scores from 34 algorithms, including: 

9 conservation scores, including:

And observed allele frequencies in: 

Moreover, dbNSFP provides related gene information, including:


For a full list of data included in dbNSFP, please check the README files in the Releases page.


We welcome developers of functional prediction methods to provide their predictions and scores to the database. Please contact us at collaboration@dbnsfp.org.